George Colberg
Lewis Gruber
Lewis Gruber is Chief Executive Officer and a founder of SIWA Therapeutics, Inc. (“SIWA”). SIWA is a pre-clinical stage biopharmaceutical company with a first-in-class humanized monoclonal antibody (“mAb”) that binds to a SIWA-identified advanced glycation endproduct target antigen on senescent cells (“SCs”) and removes them. SCs accumulate with aging or exposure to stress and have a causative role in age-related dysfunction and degenerative diseases including. by way of example, many cancers, and neurodegenerative diseases such as Parkinson’s, ALS, and Alzheimer’s Disease, SIWA has the complete sequence of SIWA 318H, which provides the basis for senescent cell clearance in any mammalian species. Prior to founding SIWA, Mr. Gruber was a founder of Arryx, Inc., and served as its CEO from 2000 through 2005 (acquired by a publicly-held company). While Mr. Gruber was at Arryx, it received numerous awards including ones for World Economic Forum Technology Pioneer (2005) and Red Herring Top 100 Innovator for 2004. Prior to Arryx, he was a founder of Hyseq, Inc, a publicly-held genomics company (subsequently merged). He served as Hyseq’s CEO from 1994 through 2000. While CEO, Hyseq completed the largest IPO of a biotechnology company in 1997 (underwritten by Salomon Smith Barney and others) and obtained collaborations for Hyseq totaling over $10 million. The technology was sold to Beijing Genomics Institute.
